AHG stands for what in transfusion testing?

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Multiple Choice

AHG stands for what in transfusion testing?

Anti-Human Globulin is the AHG reagent. This means the reagent is an antibody directed against human immunoglobulins (and sometimes complement). In transfusion testing, AHG is used to reveal antibodies that are bound to red blood cells. In the direct antiglobulin test (DAT), the AHG reagent binds to any human IgG or C3 on the surface of red cells, causing agglutination if coating is present. In the indirect antiglobulin test (IAT), antibodies in patient serum that have bound to red cells are detected by adding AHG to bridge the cells and produce agglutination. The other phrasings would point to an antigen or describe a different concept, but AHG specifically refers to an antibody against human globulins.

Anti-Human Globulin is the AHG reagent. This means the reagent is an antibody directed against human immunoglobulins (and sometimes complement). In transfusion testing, AHG is used to reveal antibodies that are bound to red blood cells. In the direct antiglobulin test (DAT), the AHG reagent binds to any human IgG or C3 on the surface of red cells, causing agglutination if coating is present. In the indirect antiglobulin test (IAT), antibodies in patient serum that have bound to red cells are detected by adding AHG to bridge the cells and produce agglutination. The other phrasings would point to an antigen or describe a different concept, but AHG specifically refers to an antibody against human globulins.

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