Anti-D alloimmunization during pregnancy can cause which condition?

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Multiple Choice

Anti-D alloimmunization during pregnancy can cause which condition?

Anti-D alloimmunization occurs when an Rh-negative mother is exposed to Rh-positive fetal red cells and forms IgG anti-D antibodies. These IgG antibodies cross the placenta and attack Rh-positive fetal red cells, causing fetal hemolysis and anemia. The resulting fetal anemia can lead to hydrops fetalis and, after birth, severe jaundice from hemolysis. This is why the condition associated with anti-D alloimmunization is hemolytic disease of the fetus/newborn. The other options don’t reflect the fetal impact: maternal iron overload isn’t driven by anti-D, and the mother is not the sole affected party in this scenario.

Anti-D alloimmunization occurs when an Rh-negative mother is exposed to Rh-positive fetal red cells and forms IgG anti-D antibodies. These IgG antibodies cross the placenta and attack Rh-positive fetal red cells, causing fetal hemolysis and anemia. The resulting fetal anemia can lead to hydrops fetalis and, after birth, severe jaundice from hemolysis. This is why the condition associated with anti-D alloimmunization is hemolytic disease of the fetus/newborn. The other options don’t reflect the fetal impact: maternal iron overload isn’t driven by anti-D, and the mother is not the sole affected party in this scenario.

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