Based on the following reactivity pattern, which antibody is suspected? Anti-A 0, Anti-B 0, Anti-D 4+, RhC 0, A1 Cells 4+, B Cells 4+, SCI 3+, SCII 3+, SCIII 3+, Adult O cells 4+, Cord O cells 1+.

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Multiple Choice

Based on the following reactivity pattern, which antibody is suspected? Anti-A 0, Anti-B 0, Anti-D 4+, RhC 0, A1 Cells 4+, B Cells 4+, SCI 3+, SCII 3+, SCIII 3+, Adult O cells 4+, Cord O cells 1+.

H antigen is present on most red cells, serving as the common precursor to the A and B antigens. An anti-H antibody will typically react with a wide range of cells that express H, showing strong reactivity with many ABO phenotypes (A1, B, and O) and a weaker reaction with cord cells, which have lower H expression. The pattern here shows no anti-A or anti-B activity, but strong reactivity with A1 and B cells and with adult O cells, with only a weaker reaction on cord O cells—a classic sign of anti-H. Antibodies like anti-I, anti-M, or anti-S would produce more specific, antigen-driven patterns and don’t explain this broad H-antigen–dependent reactivity.

H antigen is present on most red cells, serving as the common precursor to the A and B antigens. An anti-H antibody will typically react with a wide range of cells that express H, showing strong reactivity with many ABO phenotypes (A1, B, and O) and a weaker reaction with cord cells, which have lower H expression. The pattern here shows no anti-A or anti-B activity, but strong reactivity with A1 and B cells and with adult O cells, with only a weaker reaction on cord O cells—a classic sign of anti-H. Antibodies like anti-I, anti-M, or anti-S would produce more specific, antigen-driven patterns and don’t explain this broad H-antigen–dependent reactivity.

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