Delayed transfusion reactions can occur because some antibodies are not detectable at the time of screening; which example is given?

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Multiple Choice

Delayed transfusion reactions can occur because some antibodies are not detectable at the time of screening; which example is given?

Delayed transfusion reactions occur when an antibody against donor red cells is not detectable at the time of screening, but develops or rises after exposure to transfused cells. Anti-E is a classic example: it's an alloantibody against the E antigen of the Rh system that can be missed during pretransfusion testing because its titer can be low or it may react weakly with screening cells. After a transfusion containing E antigen, the antibody can rise and then destroy the transfused E-positive red cells days later, causing a delayed hemolytic transfusion reaction. ABO incompatibility would usually trigger an immediate and often more severe reaction that is detected by ABO typing. Contamination would cause reaction from infection or sepsis, not an antibody-mediated delayed hemolysis. A patient’s other infection explains fever or clinical symptoms unrelated to a specific RBC antibody.

Delayed transfusion reactions occur when an antibody against donor red cells is not detectable at the time of screening, but develops or rises after exposure to transfused cells. Anti-E is a classic example: it's an alloantibody against the E antigen of the Rh system that can be missed during pretransfusion testing because its titer can be low or it may react weakly with screening cells. After a transfusion containing E antigen, the antibody can rise and then destroy the transfused E-positive red cells days later, causing a delayed hemolytic transfusion reaction.

ABO incompatibility would usually trigger an immediate and often more severe reaction that is detected by ABO typing. Contamination would cause reaction from infection or sepsis, not an antibody-mediated delayed hemolysis. A patient’s other infection explains fever or clinical symptoms unrelated to a specific RBC antibody.

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