In an ABO discrepancy case with suspected acquired B antigen, which test helps confirm acquired status?

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Multiple Choice

In an ABO discrepancy case with suspected acquired B antigen, which test helps confirm acquired status?

Acquired B antigen is a temporary phenomenon where a bacterial modification in the gut creates a B-like determinant on red cells, making forward typing appear as B even if the true ABO type isn’t B. To confirm that this B-like signal on the red cells is acquired rather than intrinsic, you look at ABH secretor status by testing saliva for ABH antigens. If secretor testing shows ABH antigens in secretions that match the person’s genetic type, but the red cells display B antigen, it supports that the B antigen is acquired. In other words, secretor studies help distinguish RBC-detected B antigen that is acquired from the patient’s true ABO type. Cord blood typing wouldn’t address an acquired phenomenon in an adult. A1 cell typing is used to resolve general ABO discrepancies but isn’t specific for confirming an acquired B process. Saline replacement is a technique mainly for distinguishing rouleaux or non-specific agglutination, not for establishing acquired B status.

Acquired B antigen is a temporary phenomenon where a bacterial modification in the gut creates a B-like determinant on red cells, making forward typing appear as B even if the true ABO type isn’t B. To confirm that this B-like signal on the red cells is acquired rather than intrinsic, you look at ABH secretor status by testing saliva for ABH antigens. If secretor testing shows ABH antigens in secretions that match the person’s genetic type, but the red cells display B antigen, it supports that the B antigen is acquired. In other words, secretor studies help distinguish RBC-detected B antigen that is acquired from the patient’s true ABO type.

Cord blood typing wouldn’t address an acquired phenomenon in an adult. A1 cell typing is used to resolve general ABO discrepancies but isn’t specific for confirming an acquired B process. Saline replacement is a technique mainly for distinguishing rouleaux or non-specific agglutination, not for establishing acquired B status.

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