Lewis inheritance: Lele HH Sese yields which phenotype?

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Multiple Choice

Lewis inheritance: Lele HH Sese yields which phenotype?

Lewis antigens on red cells come from two genes: Le and Se, and they depend on whether H antigen is present. The Le gene makes Le^a; the Se gene supplies the enzyme that converts Le^a to Le^b in secretions, and those soluble antigens can be adsorbed onto the red cell surface. With Le/le, one Le allele is available, so Le can be produced, and with Se/se (secretors present), Le^b is produced as well. Since the H antigen is present (HH), there is substrate to express these determinants on the red cell surface. The result is Le^b present and Le^a absent on the red cells, i.e., Le(a-b+).

Lewis antigens on red cells come from two genes: Le and Se, and they depend on whether H antigen is present. The Le gene makes Le^a; the Se gene supplies the enzyme that converts Le^a to Le^b in secretions, and those soluble antigens can be adsorbed onto the red cell surface. With Le/le, one Le allele is available, so Le can be produced, and with Se/se (secretors present), Le^b is produced as well. Since the H antigen is present (HH), there is substrate to express these determinants on the red cell surface. The result is Le^b present and Le^a absent on the red cells, i.e., Le(a-b+).

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