What best describes a major crossmatch?

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Multiple Choice

What best describes a major crossmatch?

The major crossmatch is about detecting antibodies in the recipient that could react with donor red cells. It uses the recipient’s plasma against donor red cells and is performed in multiple phases to catch different kinds of antibodies: immediate spin, incubation at 37°C, and the antiglobulin (AHG) phase. This full approach ensures that both clinically significant IgG antibodies and those that require enhancement are detected before transfusion. It’s done when there are known antibodies or discrepancies in testing, and for red cell transfusions in general. It is not just ABO compatibility, it isn’t donor serum against recipient cells, and it isn’t used for plasma transfusion.

The major crossmatch is about detecting antibodies in the recipient that could react with donor red cells. It uses the recipient’s plasma against donor red cells and is performed in multiple phases to catch different kinds of antibodies: immediate spin, incubation at 37°C, and the antiglobulin (AHG) phase. This full approach ensures that both clinically significant IgG antibodies and those that require enhancement are detected before transfusion. It’s done when there are known antibodies or discrepancies in testing, and for red cell transfusions in general. It is not just ABO compatibility, it isn’t donor serum against recipient cells, and it isn’t used for plasma transfusion.

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