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Multiple Choice

What does urine neutralize?

Urine contains soluble Sd(a) antigen, so antibodies directed against Sd(a) can be neutralized by it. When anti-Sd(a) is mixed with urine, the Sd(a) antigens in the urine bind the antibody’s binding sites, preventing the antibody from reacting with Sd(a) on red cells in testing. This neutralization confirms the antibody’s specificity for the Sd(a) antigen. The other antibodies listed do not have their reactivity predictably blocked by urine, so they wouldn’t be neutralized in this way.

Urine contains soluble Sd(a) antigen, so antibodies directed against Sd(a) can be neutralized by it. When anti-Sd(a) is mixed with urine, the Sd(a) antigens in the urine bind the antibody’s binding sites, preventing the antibody from reacting with Sd(a) on red cells in testing. This neutralization confirms the antibody’s specificity for the Sd(a) antigen. The other antibodies listed do not have their reactivity predictably blocked by urine, so they wouldn’t be neutralized in this way.