What does ZZAP denature?

Master the CAMLPR Transfusion Test with interactive questions and detailed explanations. Boost your knowledge and ensure you're exam-ready with comprehensive study resources!

Multiple Choice

What does ZZAP denature?

ZZAP uses a reducing agent to break disulfide bonds and a proteolytic enzyme to digest certain membrane proteins. Many protein-based red cell antigens depend on the intact structure formed by those disulfide bonds. When ZZAP disrupts the protein conformation, the epitopes for Kell, M, N, S, and Duffy antigens are disrupted, so red cells treated with ZZAP lose these antigens. In contrast, Rh and H antigens are less affected by this treatment, so they tend to remain detectable. This is why the denatured set listed is Kell, M, N, S, and Duffy.

ZZAP uses a reducing agent to break disulfide bonds and a proteolytic enzyme to digest certain membrane proteins. Many protein-based red cell antigens depend on the intact structure formed by those disulfide bonds. When ZZAP disrupts the protein conformation, the epitopes for Kell, M, N, S, and Duffy antigens are disrupted, so red cells treated with ZZAP lose these antigens. In contrast, Rh and H antigens are less affected by this treatment, so they tend to remain detectable. This is why the denatured set listed is Kell, M, N, S, and Duffy.

More practice questions