What is the effect of leukoreduction on transfusion reactions?

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Multiple Choice

What is the effect of leukoreduction on transfusion reactions?

Leukoreduction removes most donor white blood cells from blood products, cutting down on the immune triggers that can cause transfusion reactions. By lowering the amount of donor leukocyte antigens and the cytokines they release during storage, the recipient’s immune system is less stimulated. This leads to fewer febrile nonhemolytic transfusion reactions, which are fevers and chills driven by immune responses to leukocyte-derived substances, and less alloimmunization to HLA antigens on donor leukocytes, reducing the risk of future platelet refractoriness. It does not increase infection risk; in some high-risk situations it can reduce certain infections, such as CMV transmission via leukocytes.

Leukoreduction removes most donor white blood cells from blood products, cutting down on the immune triggers that can cause transfusion reactions. By lowering the amount of donor leukocyte antigens and the cytokines they release during storage, the recipient’s immune system is less stimulated. This leads to fewer febrile nonhemolytic transfusion reactions, which are fevers and chills driven by immune responses to leukocyte-derived substances, and less alloimmunization to HLA antigens on donor leukocytes, reducing the risk of future platelet refractoriness. It does not increase infection risk; in some high-risk situations it can reduce certain infections, such as CMV transmission via leukocytes.

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