What is the purpose of leukoreduced blood products?

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Multiple Choice

What is the purpose of leukoreduced blood products?

Leukoreduction removes donor white blood cells from blood products. This lowers the amount of donor leukocytes and related cytokines that the recipient is exposed to, which in turn reduces immune and inflammatory reactions after transfusion. Specifically, it lowers the risk of febrile nonhemolytic transfusion reactions and decreases alloimmunization to leukocyte (notably HLA) antigens that can develop with repeated transfusions. It can also lessen the chance of transmitting CMV in susceptible patients, since CMV is often carried in white cells. This approach doesn’t raise clotting factors, improve oxygen delivery, or address iron overload, because those outcomes are not driven by leukocytes.

Leukoreduction removes donor white blood cells from blood products. This lowers the amount of donor leukocytes and related cytokines that the recipient is exposed to, which in turn reduces immune and inflammatory reactions after transfusion. Specifically, it lowers the risk of febrile nonhemolytic transfusion reactions and decreases alloimmunization to leukocyte (notably HLA) antigens that can develop with repeated transfusions. It can also lessen the chance of transmitting CMV in susceptible patients, since CMV is often carried in white cells. This approach doesn’t raise clotting factors, improve oxygen delivery, or address iron overload, because those outcomes are not driven by leukocytes.

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