When should irradiated blood components be used?

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Multiple Choice

When should irradiated blood components be used?

Irradiation of blood components is used to prevent transfusion-associated graft-versus-host disease by inactivating donor T lymphocytes in the transfused product. This protects recipients whose immune systems are unable to control those donor cells. Therefore, irradiated components are indicated for groups at risk, including immunocompromised recipients, patients with hematologic malignancies, intrauterine exposure, and other TA-GVHD risk groups. It isn’t needed for healthy adults undergoing minor procedures or for all transfusions, and neonatal transfusions are irradiated only when there is a TA-GVHD risk. The goal is to inactivate donor lymphocytes before they can cause graft-versus-host disease.

Irradiation of blood components is used to prevent transfusion-associated graft-versus-host disease by inactivating donor T lymphocytes in the transfused product. This protects recipients whose immune systems are unable to control those donor cells. Therefore, irradiated components are indicated for groups at risk, including immunocompromised recipients, patients with hematologic malignancies, intrauterine exposure, and other TA-GVHD risk groups. It isn’t needed for healthy adults undergoing minor procedures or for all transfusions, and neonatal transfusions are irradiated only when there is a TA-GVHD risk. The goal is to inactivate donor lymphocytes before they can cause graft-versus-host disease.

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