Which ABO/Rh group corresponds to the following serology: Anti-A 4+, Anti-B 0', Anti-D 0, A1 Cells 2+, B cells 4+, Dolichos biflorus 0?

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Multiple Choice

Which ABO/Rh group corresponds to the following serology: Anti-A 4+, Anti-B 0', Anti-D 0, A1 Cells 2+, B cells 4+, Dolichos biflorus 0?

The key idea is distinguishing A1 from A2 within the A group and identifying anti-A1 antibodies using the Dolichos biflorus test. Here the serum shows anti-A activity (4+), and testing with A1 cells is positive (2+), meaning there are antibodies in the serum that react with A1 antigen. Dolichos biflorus is a lectin that binds specifically to A1 antigen; a negative Dolichos result (0) indicates the patient’s red cells do not express A1 antigen. Putting those clues together, the red cells must be A2 (not A1). Since the anti-A detected in the serum reacts with A1 antigen but not with A2 antigen, this pattern is consistent with an A2 individual who has anti-A1 antibodies circulating. The Rh result is negative (no anti-D detected). So the overall serology corresponds to an A2 Rh-negative individual with anti-A1 antibodies.

The key idea is distinguishing A1 from A2 within the A group and identifying anti-A1 antibodies using the Dolichos biflorus test.

Here the serum shows anti-A activity (4+), and testing with A1 cells is positive (2+), meaning there are antibodies in the serum that react with A1 antigen. Dolichos biflorus is a lectin that binds specifically to A1 antigen; a negative Dolichos result (0) indicates the patient’s red cells do not express A1 antigen. Putting those clues together, the red cells must be A2 (not A1).

Since the anti-A detected in the serum reacts with A1 antigen but not with A2 antigen, this pattern is consistent with an A2 individual who has anti-A1 antibodies circulating. The Rh result is negative (no anti-D detected).

So the overall serology corresponds to an A2 Rh-negative individual with anti-A1 antibodies.

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