Which antibodies are associated with HDFN?

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Multiple Choice

Which antibodies are associated with HDFN?

HDFN happens when maternal IgG antibodies against fetal red cell antigens cross the placenta and attack the fetal RBCs, causing destruction and anemia that can lead to jaundice and other complications after birth. Several antibody specificities across different blood group systems can cause this condition: Rh(D) antibodies are the classic and can produce severe HDFN; Kell antibodies are also strongly associated with significant hemolysis; antibodies to Duffy, Kidd, and Lutheran antigens can cause HDFN to varying degrees; and ABO antibodies, though often milder, can contribute to HDFN as well. Because all of these antibody families are implicated in HDFN, the list that includes ABO, Rh, Kell, Duffy, Kidd, and Lutherans best reflects the antibodies associated with HDFN. The other options omit one or more of these important antibodies, making them less complete.

HDFN happens when maternal IgG antibodies against fetal red cell antigens cross the placenta and attack the fetal RBCs, causing destruction and anemia that can lead to jaundice and other complications after birth. Several antibody specificities across different blood group systems can cause this condition: Rh(D) antibodies are the classic and can produce severe HDFN; Kell antibodies are also strongly associated with significant hemolysis; antibodies to Duffy, Kidd, and Lutheran antigens can cause HDFN to varying degrees; and ABO antibodies, though often milder, can contribute to HDFN as well. Because all of these antibody families are implicated in HDFN, the list that includes ABO, Rh, Kell, Duffy, Kidd, and Lutherans best reflects the antibodies associated with HDFN. The other options omit one or more of these important antibodies, making them less complete.

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