Which antibodies are cold reacting?

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Multiple Choice

Which antibodies are cold reacting?

Cold-reacting antibodies are those that bind red cells at temperatures below body temperature, typically IgM antibodies that react at room temperature or colder. The antibodies in this group commonly seen in practice include those directed against I and related antigens (anti-I, sometimes anti-IH), anti-P1, anti-M, anti-N, and antibodies against Lewis antigens. ABO antibodies (anti-A and anti-B) are also naturally occurring IgM antibodies that can react at room temperature or lower. Because these antibodies are active at cooler temperatures, they are classically described as cold-reacting. The other antibody groups listed are mainly IgG and react best at or after warming to body temperature (37°C) in the antiglobulin phase, making them warm-reacting rather than cold. Therefore, the set that includes Lewis, I, P, M, N, and ABO/H antigens represents the cold-reacting antibodies.

Cold-reacting antibodies are those that bind red cells at temperatures below body temperature, typically IgM antibodies that react at room temperature or colder. The antibodies in this group commonly seen in practice include those directed against I and related antigens (anti-I, sometimes anti-IH), anti-P1, anti-M, anti-N, and antibodies against Lewis antigens. ABO antibodies (anti-A and anti-B) are also naturally occurring IgM antibodies that can react at room temperature or lower. Because these antibodies are active at cooler temperatures, they are classically described as cold-reacting.

The other antibody groups listed are mainly IgG and react best at or after warming to body temperature (37°C) in the antiglobulin phase, making them warm-reacting rather than cold. Therefore, the set that includes Lewis, I, P, M, N, and ABO/H antigens represents the cold-reacting antibodies.

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