Which antibodies are destroyed by enzymes?

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Multiple Choice

Which antibodies are destroyed by enzymes?

Enzymes used to treat red cells remove specific antigen sites from the cell surface, so antibodies that target those sites no longer bind after enzyme exposure. The antigens most affected by proteolytic enzymes are those in the Duffy and MNSs systems. Antibodies against Duffy (Fya, Fyb) and against MNSs (M, N, S, s) are typically inactivated when tested against enzyme-treated cells because the enzyme destroys or alters the epitopes they recognize. That makes these antibodies the ones destroyed by enzymes. Other antibody specificities, such as those against Kell or most Rh antigens, are not reliably destroyed by enzyme treatment, and Kidd antibodies may even be enhanced in some cases, so they are not the correct pair for “destroyed by enzymes.”

Enzymes used to treat red cells remove specific antigen sites from the cell surface, so antibodies that target those sites no longer bind after enzyme exposure. The antigens most affected by proteolytic enzymes are those in the Duffy and MNSs systems. Antibodies against Duffy (Fya, Fyb) and against MNSs (M, N, S, s) are typically inactivated when tested against enzyme-treated cells because the enzyme destroys or alters the epitopes they recognize. That makes these antibodies the ones destroyed by enzymes.

Other antibody specificities, such as those against Kell or most Rh antigens, are not reliably destroyed by enzyme treatment, and Kidd antibodies may even be enhanced in some cases, so they are not the correct pair for “destroyed by enzymes.”

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