Which antibody group is associated with malarial resistance?

Master the CAMLPR Transfusion Test with interactive questions and detailed explanations. Boost your knowledge and ensure you're exam-ready with comprehensive study resources!

Multiple Choice

Which antibody group is associated with malarial resistance?

The key idea is that the Duffy antigen on red blood cells serves as the entry receptor for Plasmodium vivax. When someone expresses Fy antigens (Fy(a) or Fy(b)), P. vivax can attach and invade the red cell, which allows the infection to occur. But individuals who are Fy(a-b-) lack these Duffy antigens on their red cells, so the parasite cannot gain entry. This makes Fy(a-b-) individuals resistant to vivax malaria, a phenomenon observed in populations where the Duffy-negative phenotype is common. The other blood group systems listed don’t determine susceptibility to P. vivax invasion, so they aren’t linked to malarial resistance. Therefore, the Fy(a-b-) phenotype is the one associated with resistance to this malaria species.

The key idea is that the Duffy antigen on red blood cells serves as the entry receptor for Plasmodium vivax. When someone expresses Fy antigens (Fy(a) or Fy(b)), P. vivax can attach and invade the red cell, which allows the infection to occur. But individuals who are Fy(a-b-) lack these Duffy antigens on their red cells, so the parasite cannot gain entry. This makes Fy(a-b-) individuals resistant to vivax malaria, a phenomenon observed in populations where the Duffy-negative phenotype is common.

The other blood group systems listed don’t determine susceptibility to P. vivax invasion, so they aren’t linked to malarial resistance. Therefore, the Fy(a-b-) phenotype is the one associated with resistance to this malaria species.

More practice questions