Which antibody is not associated with HDFN?

Master the CAMLPR Transfusion Test with interactive questions and detailed explanations. Boost your knowledge and ensure you're exam-ready with comprehensive study resources!

Multiple Choice

Which antibody is not associated with HDFN?

Hemolytic disease of the fetus and newborn happens when maternal IgG antibodies targeting fetal red cell antigens cross the placenta and destroy the fetus’s RBCs. The most significant associations are with Rh (D) antibodies and Kell antibodies, which can cause substantial fetal anemia and even hydrops; ABO incompatibility can also cause HDFN, though usually milder. Antibodies in the MNSs system, such as anti-M and anti-N, are typically not a major cause of HDFN because these antibodies are often IgM (which do not cross the placenta) or, if IgG, tend to produce only minimal or no hemolysis. Therefore, MNSs antibodies are not generally associated with HDFN, making them the best answer.

Hemolytic disease of the fetus and newborn happens when maternal IgG antibodies targeting fetal red cell antigens cross the placenta and destroy the fetus’s RBCs. The most significant associations are with Rh (D) antibodies and Kell antibodies, which can cause substantial fetal anemia and even hydrops; ABO incompatibility can also cause HDFN, though usually milder. Antibodies in the MNSs system, such as anti-M and anti-N, are typically not a major cause of HDFN because these antibodies are often IgM (which do not cross the placenta) or, if IgG, tend to produce only minimal or no hemolysis. Therefore, MNSs antibodies are not generally associated with HDFN, making them the best answer.

More practice questions