Which antibody is unaffected by enzymes, though the antigen can be destroyed with sulfhydryl reagents?

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Kell antibodies fit this pattern. The Kell antigen shows resistance to proteolytic enzyme treatment of red cells, so antibodies against Kell will still react with enzyme-treated cells. However, Kell antigens are destroyed by sulfhydryl reagents (which break disulfide bonds), so treating the cells with these reagents removes the antigen and abolishes anti-Kell reactivity. This combination—reactivity preserved after enzyme treatment but lost after sulfhydryl treatment—identifies the Kell system.