Which infectious disease screenings are routinely performed on donor blood?

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Multiple Choice

Which infectious disease screenings are routinely performed on donor blood?

Donor blood is screened for infectious agents to prevent transmission of illness through transfusion, using a broad panel that covers the most important viruses and other pathogens. The combination shown includes HIV-1/2 testing to catch current and recent infection, hepatitis B surface antigen to detect active HBV infection, hepatitis B core antibodies to identify exposures that might not yet show surface antigen or indicate occult infection, hepatitis C antibodies to detect exposure to HCV, and a syphilis test to prevent transmission of Treponema pallidum. This multi-marker approach minimizes the chance that an infected unit is used. Other options miss one or more of these protective tests—omitting syphilis, for example, leaves a known transfusion risk unaddressed, and omitting HBV core antibodies or HBV surface antigen can miss different phases of HBV infection.

Donor blood is screened for infectious agents to prevent transmission of illness through transfusion, using a broad panel that covers the most important viruses and other pathogens. The combination shown includes HIV-1/2 testing to catch current and recent infection, hepatitis B surface antigen to detect active HBV infection, hepatitis B core antibodies to identify exposures that might not yet show surface antigen or indicate occult infection, hepatitis C antibodies to detect exposure to HCV, and a syphilis test to prevent transmission of Treponema pallidum. This multi-marker approach minimizes the chance that an infected unit is used.

Other options miss one or more of these protective tests—omitting syphilis, for example, leaves a known transfusion risk unaddressed, and omitting HBV core antibodies or HBV surface antigen can miss different phases of HBV infection.

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