Which of the following is a cold-reacting antibody?

Master the CAMLPR Transfusion Test with interactive questions and detailed explanations. Boost your knowledge and ensure you're exam-ready with comprehensive study resources!

Multiple Choice

Which of the following is a cold-reacting antibody?

Cold-reacting antibodies are typically IgM and react best at low temperatures. Anti-I is the classic example, targeting the I antigen on red blood cells. It binds at cooler temperatures (often tested at room temperature or colder) and can cause RBC agglutination in vitro or in the periphery when the body cools. In contrast, antibodies against Rh, Kell, and Duffy are usually IgG and react at warmer temperatures (around 37°C) or with the antiglobulin test, making them more clinically significant for transfusion and pregnancy. Therefore, the antibody that fits the description of cold-reacting is the one directed against the I antigen.

Cold-reacting antibodies are typically IgM and react best at low temperatures. Anti-I is the classic example, targeting the I antigen on red blood cells. It binds at cooler temperatures (often tested at room temperature or colder) and can cause RBC agglutination in vitro or in the periphery when the body cools. In contrast, antibodies against Rh, Kell, and Duffy are usually IgG and react at warmer temperatures (around 37°C) or with the antiglobulin test, making them more clinically significant for transfusion and pregnancy. Therefore, the antibody that fits the description of cold-reacting is the one directed against the I antigen.

More practice questions