Which of the following sets are the second-order genes?

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Multiple Choice

Which of the following sets are the second-order genes?

In the Rh blood group system, every person has two haplotypes, and the D antigen is the most prominent feature (the first-order aspect). The other part of the RhCE cluster—the C/c and E/e antigens encoded on the RhCE locus—forms the second-order genes. These second-order genes are the non-D components that can pair with a D-containing haplotype on the opposite chromosome to complete the genotype and determine the full Rh phenotype. The valid second-order gene sets are the pairings where a D-containing haplotype is matched with a corresponding non-D RhCE haplotype on the other chromosome: one is R0 paired with Dce, another is r' paired with dCe, and the third is r'' paired with dcE. These reflect the recognized second-order alleles (R0, R1, R2, Rz for the D-containing side and the recessive r-types for the non-D side) and how they combine to describe the two-chromosome Rh genotype. Other pairings do not fit the standard second-order gene combinations, so they aren’t considered the second-order sets.

In the Rh blood group system, every person has two haplotypes, and the D antigen is the most prominent feature (the first-order aspect). The other part of the RhCE cluster—the C/c and E/e antigens encoded on the RhCE locus—forms the second-order genes. These second-order genes are the non-D components that can pair with a D-containing haplotype on the opposite chromosome to complete the genotype and determine the full Rh phenotype.

The valid second-order gene sets are the pairings where a D-containing haplotype is matched with a corresponding non-D RhCE haplotype on the other chromosome: one is R0 paired with Dce, another is r' paired with dCe, and the third is r'' paired with dcE. These reflect the recognized second-order alleles (R0, R1, R2, Rz for the D-containing side and the recessive r-types for the non-D side) and how they combine to describe the two-chromosome Rh genotype.

Other pairings do not fit the standard second-order gene combinations, so they aren’t considered the second-order sets.

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