Which option best describes a positive control example for anti-C testing?

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Multiple Choice

Which option best describes a positive control example for anti-C testing?

A positive control for anti-C testing must have the C antigen expressed on red cells so the antibody reagent can bind and produce a reaction, confirming the test is functioning. The genotype that is described as heterozygous for C antigen carries one C-bearing chromosome and one without, so the red cells display the C antigen. This ensures a clear positive reaction if anti-C is present, validating the test. The other options either lack C antigen entirely, or would be strongly C-positive, which can still work but does not illustrate a typical positive-control example as directly. Thus, the heterozygous C-antigen–carrying genotype best serves as the positive control.

A positive control for anti-C testing must have the C antigen expressed on red cells so the antibody reagent can bind and produce a reaction, confirming the test is functioning.

The genotype that is described as heterozygous for C antigen carries one C-bearing chromosome and one without, so the red cells display the C antigen. This ensures a clear positive reaction if anti-C is present, validating the test. The other options either lack C antigen entirely, or would be strongly C-positive, which can still work but does not illustrate a typical positive-control example as directly. Thus, the heterozygous C-antigen–carrying genotype best serves as the positive control.

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