Which result best distinguishes the A1 subgroup from A2 in serology?

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Multiple Choice

Which result best distinguishes the A1 subgroup from A2 in serology?

The test hinges on a receptor that differentiates A1 from A2 by recognizing the A1 antigen. Dolichos biflorus lectin binds specifically to the A1 antigen present on A1 cells, producing strong agglutination. A2 cells, which carry the A2 antigen rather than A1, typically do not show this strong reaction. So seeing strong agglutination with Dolichos biflorus on the A1 cells is the clearest serologic distinction between A1 and A2. Other statements either misstate how A1 reacts to the Dolichos biflorus reagent or rely on anti-A1 reactivity that isn’t as reliable for separating A1 from A2.

The test hinges on a receptor that differentiates A1 from A2 by recognizing the A1 antigen. Dolichos biflorus lectin binds specifically to the A1 antigen present on A1 cells, producing strong agglutination. A2 cells, which carry the A2 antigen rather than A1, typically do not show this strong reaction. So seeing strong agglutination with Dolichos biflorus on the A1 cells is the clearest serologic distinction between A1 and A2. Other statements either misstate how A1 reacts to the Dolichos biflorus reagent or rely on anti-A1 reactivity that isn’t as reliable for separating A1 from A2.

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