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Multiple Choice

Which statement about alloabsorption is true?

Alloabsorption relies on using donor red cells that express specific antigens to remove matching alloantibodies from a patient’s serum. By absorbing these known antibodies, the remaining serum can be tested again to reveal any additional alloantibodies that were previously hidden or difficult to detect. This helps in accurately identifying the full antibody profile so compatible blood can be chosen for transfusion. It doesn’t pertain to ABO typing, since that process involves the patient’s own antibodies reacting with ABO antigens and is not about removing specific non-ABO alloantibodies. It’s not about eliminating autoantibodies—those are addressed with other methods like autoadsorption using the patient’s own red cells. And it doesn’t aim to increase antibody production; adsorption removes antibodies from the serum rather than stimulating their production.

Alloabsorption relies on using donor red cells that express specific antigens to remove matching alloantibodies from a patient’s serum. By absorbing these known antibodies, the remaining serum can be tested again to reveal any additional alloantibodies that were previously hidden or difficult to detect. This helps in accurately identifying the full antibody profile so compatible blood can be chosen for transfusion.

It doesn’t pertain to ABO typing, since that process involves the patient’s own antibodies reacting with ABO antigens and is not about removing specific non-ABO alloantibodies. It’s not about eliminating autoantibodies—those are addressed with other methods like autoadsorption using the patient’s own red cells. And it doesn’t aim to increase antibody production; adsorption removes antibodies from the serum rather than stimulating their production.