Which statement about the AHG phase is correct?

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Multiple Choice

Which statement about the AHG phase is correct?

The AHG phase targets antibodies that stay bound to red cells and react at 37°C, revealing clinically significant IgG alloantibodies that can cause hemolytic reactions. This phase uses anti-human globulin to detect those IgG-coated cells, which is essential in crossmatching when non-ABO antibodies may be present. That’s why the correct statement is that this phase detects clinically significant IgG antibodies. ABO incompatibility is typically detected at the immediate-spin phase because ABO antibodies are mainly IgM and react at room temperature. The AHG phase is not limited to ABO issues, and it helps uncover other IgG antibodies against RBC antigens such as Rh, Kell, Duffy, Kidd, and MNS. IgM antibodies generally do not require the AHG phase to be detected; they usually cause reactions at the IS phase and may not be detectable in the AHG phase. Finally, the AHG phase is indeed used in crossmatching to ensure compatibility when IgG antibodies are present, so saying it is not used in crossmatching is incorrect.

The AHG phase targets antibodies that stay bound to red cells and react at 37°C, revealing clinically significant IgG alloantibodies that can cause hemolytic reactions. This phase uses anti-human globulin to detect those IgG-coated cells, which is essential in crossmatching when non-ABO antibodies may be present. That’s why the correct statement is that this phase detects clinically significant IgG antibodies.

ABO incompatibility is typically detected at the immediate-spin phase because ABO antibodies are mainly IgM and react at room temperature. The AHG phase is not limited to ABO issues, and it helps uncover other IgG antibodies against RBC antigens such as Rh, Kell, Duffy, Kidd, and MNS.

IgM antibodies generally do not require the AHG phase to be detected; they usually cause reactions at the IS phase and may not be detectable in the AHG phase.

Finally, the AHG phase is indeed used in crossmatching to ensure compatibility when IgG antibodies are present, so saying it is not used in crossmatching is incorrect.

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