Which statement reflects donor exposure management in neonates?

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The main idea is to reduce how many different donors a neonate is exposed to during transfusion. Each new donor introduces fresh donor antigens to a baby with an immature immune system, increasing the chance of alloimmunization—the production of antibodies against donor red cell or platelet antigens. alloimmunization can lead to transfusion problems in the future, such as hemolytic reactions or refractoriness to further transfusions. There is also a cumulative risk of transfusion-transmitted infection or febrile/transfusion reactions with more donor exposures. So the safest, most prudent approach is to minimize donor exposures by using the same donor’s units for multiple transfusions when possible and appropriate, maintaining compatibility, and avoiding unnecessary additional donor contacts. In contrast, increasing exposures or ignoring exposure risks would raise the likelihood of complications.