Which step addresses an ABO false positive caused by rouleaux?

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Multiple Choice

Which step addresses an ABO false positive caused by rouleaux?

Rouleaux are stacks of red cells that can resemble positive agglutination in ABO typing, caused by high plasma proteins or dehydration. To tell apart rouleaux from true antigen–antibody reactions, you perform saline replacement: you replace the plasma with saline and re-check. If the apparent agglutination disappears, it was due to rouleaux; if it persists, it’s a real ABO reaction. This makes saline replacement the step that specifically addresses a false positive caused by rouleaux. Increasing RBC washing can remove some plasma proteins but doesn’t directly dissolve rouleaux; a fresh reagent or a different instrument doesn’t target this issue.

Rouleaux are stacks of red cells that can resemble positive agglutination in ABO typing, caused by high plasma proteins or dehydration. To tell apart rouleaux from true antigen–antibody reactions, you perform saline replacement: you replace the plasma with saline and re-check. If the apparent agglutination disappears, it was due to rouleaux; if it persists, it’s a real ABO reaction. This makes saline replacement the step that specifically addresses a false positive caused by rouleaux. Increasing RBC washing can remove some plasma proteins but doesn’t directly dissolve rouleaux; a fresh reagent or a different instrument doesn’t target this issue.

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