Which substance would neutralize Anti-Chido/Rogers?

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Multiple Choice

Which substance would neutralize Anti-Chido/Rogers?

Neutralization tests rely on a soluble form of the antigen to soak up the antibody so it can’t bind to cells in testing. Anti-Chido/Rogers targets epitopes on the C4 component of complement, which are carried in serum as CH/Rg antigens. Mixing the antibody with serum provides those CH/Rg epitopes in solution, binding the antibody and removing its reactivity in serologic tests. That makes serum the right neutralizing substance for Anti-Chido/Rogers. The other substances correspond to different antigen systems (Lewis, P1, Sda) and would only neutralize antibodies specific to those targets, not anti-Chido/Rogers.

Neutralization tests rely on a soluble form of the antigen to soak up the antibody so it can’t bind to cells in testing. Anti-Chido/Rogers targets epitopes on the C4 component of complement, which are carried in serum as CH/Rg antigens. Mixing the antibody with serum provides those CH/Rg epitopes in solution, binding the antibody and removing its reactivity in serologic tests. That makes serum the right neutralizing substance for Anti-Chido/Rogers. The other substances correspond to different antigen systems (Lewis, P1, Sda) and would only neutralize antibodies specific to those targets, not anti-Chido/Rogers.

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