Which two Rh antibodies commonly occur together?

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RhCE antigens C/c and E/e are encoded by the same gene and tend to be inherited together on common haplotypes. Because of this genetic linkage, when a person is immunized against one of these antigens, they are often exposed to the other as well. As a result, anti-E frequently appears alongside anti-c in the same individual. This paired pattern matters in transfusion testing because detecting anti-E should prompt evaluation for anti-c too, since both can cause transfusion reactions if donor cells carry the corresponding antigens. The other pairings don’t show this consistent co-occurrence as a rule, so anti-E and anti-c is the most expected combined antibody pattern.