Why might plasma be sourced from male donors to reduce TRALI risk?

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Multiple Choice

Why might plasma be sourced from male donors to reduce TRALI risk?

TRALI is driven by donor antibodies in plasma that react with recipient leukocytes, specifically anti-HLA and anti-HNA antibodies. Donors who have been exposed to fetal antigens during pregnancy can develop these antibodies, so plasma from women who have been pregnant often contains them. Male donors, especially those who have not been pregnant, have a much lower prevalence of these antibodies. Using plasma from male donors lowers the chance that transfused plasma contains antibodies that could trigger a leukocyte-mediated reaction in the lungs, thereby reducing TRALI risk. This concept is about the immunologic content of the plasma, not about shelf life, fibrinogen levels, or cost.

TRALI is driven by donor antibodies in plasma that react with recipient leukocytes, specifically anti-HLA and anti-HNA antibodies. Donors who have been exposed to fetal antigens during pregnancy can develop these antibodies, so plasma from women who have been pregnant often contains them. Male donors, especially those who have not been pregnant, have a much lower prevalence of these antibodies. Using plasma from male donors lowers the chance that transfused plasma contains antibodies that could trigger a leukocyte-mediated reaction in the lungs, thereby reducing TRALI risk. This concept is about the immunologic content of the plasma, not about shelf life, fibrinogen levels, or cost.

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